|
KMID : 0379520210370040485
|
|
한국독성학회지
2021 Volume.37 No. 4 p.485 ~ p.493
|
|
|
Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer
|
|
Komoto Tatiana Takahasi
Lee Jae-Hak
Lertpatipanpong Pattawika
Ryu Jun-Sun
Marins Mozart
Fachin Ana Lucia
Baek Seung-Joon
|
|
|
Abstract
|
|
|
|
Despite intensive research efforts in recent decades, cancer remains a leading cause of death worldwide. The chalcone family is a promising group of phytochemicals for therapeutic use against cancer development. Naturally-occurring chalcones, as well as synthetic chalcone analogues, have shown many beneficial biological properties, including anti-inflammatory, antioxidant, and anti-cancer activities. In this report, trans-chalcone (TChal) was found to increase cell death in breast cancer cells, assessed using high content screening. Subsequently, using antibody array analysis, TChal was found to increase heme oxygenase-1 (HO-1) expression in TChal-treated breast cancer cells. Blocking of HO-1 by siRNA in breast cancer cells diminished the effect of TChal on cell growth inhibition. TChal-fed mice also showed less tumor growth compared to vehicle-fed mice. Overall, we found that TChal increases HO-1 expression in breast cancer cells, thereby enhancing anti-tumorigenesis. Our results suggest that HO-1 expression could be a potential new target of TChal for anti-tumorigenesis in breast cancer.
|
|
|
KEYWORD
|
|
|
Heme oxygenase-1, Trans-chalcone, High content screening, Antibody array, Breast cancer, Xenograft
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|